Wayne Rooney (knee) is definitely out of the game for the hosts, while Danny Welbeck could still be sidelined as he missed the Newcastle game with an illness.
Captain Nemanja Vidic complained of soreness in his knee after the 1-1 draw with Swansea, and could be rested again.
Shinji Kagawa (knee) is nearing full fitness but this game may prove to be too soon for him, while Anderson, Rafael and Nani (all hamstring) are scheduled to return but may have to settle for places on the bench if they are fit.
Phil Jones and Ashley Young are still recovering from knocks, but could yet make the match-day squad.
Goran Popov (hamstring) has no return date and could miss the match for the visitors against the Premier League leaders.
Steven Reid (calf/shin) and Claudio Yacob (hamstring) could make a return against United, but Steve Clarke may opt not to rush them back into the first team at Old Trafford.
- United have conceded as many goals at home this season – 13 – as Southampton, who are 17th in the league.
- After netting his fourth of the campaign against Newcastle, no other defender has more goals in the league than Patrice Evra (pictured, right).
- Robin van Persie has 61 goals in 74 Premier League games since January 2011.
- Chicharito has scored in two of his last three games against West Brom.
- West Brom have kept clean sheets in just two of their last 47 Premier League games.
- Four of Romelu Lukaku’s goals this season have come in the final 20 minutes of matches.
- The Baggies could go third with a win over United on Saturday, and would be 10 points behind them in the race for the title.
- West Brom last won at Old Trafford in 1978, taking the points in a 5-3 victory.